Physical Therapy Assistant Practice Exam

Which condition is characterized by temporary inflammation and demyelination of peripheral nerves?

1. Multiple sclerosis

2. Huntington's disease

3. Myasthenia gravis

4. Guillain-Barre syndrome

The correct answer is: Guillain-Barre syndrome

The condition characterized by temporary inflammation and demyelination of peripheral nerves is Guillain-Barre syndrome. In this disorder, the body's immune system mistakenly attacks the peripheral nervous system, leading to inflammation and loss of the protective myelin sheath that surrounds nerve fibers. This demyelination typically results in muscle weakness and can progress to paralysis. Guillain-Barre syndrome often begins with symmetrical weakness and may follow an infection or vaccination. The temporary nature of the symptoms is significant, as many patients experience gradual recovery over weeks to months, although some may have residual effects. Understanding the underlying mechanism of Guillain-Barre syndrome helps in managing the condition effectively, highlighting the importance of recognizing symptoms early and providing appropriate treatment. In contrast, the other conditions listed involve different pathophysiological processes. Multiple sclerosis primarily affects the central nervous system and involves chronic demyelination rather than acute inflammation. Huntington's disease is a neurodegenerative disorder with genetic origins that impacts movement and cognitive function, while myasthenia gravis is an autoimmune disorder that affects neuromuscular transmission rather than peripheral nerve inflammation and demyelination.